Table 3.

Performance of individual parameters in predicting pCRN, measured from statistically significant ROC curves with cut-offs determined on the basis of Youden index

Variable		AUC	SE	Cut-off	Sensitivity (%)	Specificity (%)
Cluster shade		0.685	0.0842	≤7039	92.3	41.9
Sum variance		0.687	0.0817	>74770	92.3	51.6
LRE		0.712	0.0790	>1.258	84.6	61.3
LRHGE		0.747	0.0731	>24213	100.0	54.8

AUC, area under the ROC curve; SE, standard error;LRE, long run emphasis, LRHGE, low run high grey level emphasis; pCR+Smith’s Grade = 5; pCR−, Smith’s Grade < 5; pCRN+, pCR+ plus either complete absence of residual nodal metastases or presence of nodal micrometastasis; pCRN−, Smith’s Grade < 5 and any other status of axillary lymph node metastases.