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. 2018 Mar 15;13:1539–1552. doi: 10.2147/IJN.S157519

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© 2018 Xia et al. This work is published and licensed by Dove Medical Press Limited

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(A) Tumor growth curve of the xenograft nude mice bearing HepG2 cell after intravenous administration of saline and various formulations of siRNA. (B) Morphology of all tumors stripped from the mice. (C) The body weight change of mice during the treatments. (D) The mRNA expression level of HES5 in tumors stripped from the mice after 21 days of administration. **p<0.01 vs the untreated group.

Abbreviations: HA, hyaluronic acid; HES5, hairy and enhancer of split 5; PEI, polyethylenimine; Se, selenium; siRNA, small interfering RNA.