Table 1.
Demographic and imaging characteristics of participants with non-arteritic anterior ischaemic optic neuropathy and optic neuritis.
| Variable | NAION (n = 62) |
ON (n = 27) |
p value |
|---|---|---|---|
| Age (years), mean (± SD) [range] | 53.6 (± 9.4) | 37.5 (± 12.0) | <0.001 |
| [35–85] | [19–68] | ||
| Sex (males), n (%) | 39 (63%) | 6 (22%) | <0.001 |
| Multiple sclerosis, n (%) | 0 (0%) | 9 (33%) | <0.001 |
| Symptomatic bilateral eyes involved, n (%) | 10 (16%) | 5 (19%) | 0.77 |
| Days from symptom onset to neuroimaging,mean (± SD) [range] | 15.6 (± 10.3) | 10.4 (± 8.9) | 0.024 |
| [1–33] | [0–30] | ||
| Steroids prior to image, n (%) | 8 (13%) | 0 (0%) | 0.10 |
| Patients with positive post-contrast enhancement, n (%) | 24 (39%) | 22 (81%) | <0.001 |
| Unilateral, n | 21 | 20 | |
| Bilateral, n | 3 | 2 | |
| Days from symptom onset in at least one eye to scan with positive post-contrast enhancement (± SD) | 13.4 (± 9.5) | 8.7 (± 6.6) | 0.061 |
| Patients with positive DWI signal, n (%) | 12 (19%) | 12 (44%) | 0.020 |
| Unilateral, n (%) | 10 | 10 | |
| Bilateral, n (%) | 2 | 2 | |
| Days from symptom onset in at least one eye to scan with positive DWI (± SD) | 13.4 (± 8.6) | 6.6 (± 3.8) | 0.024 |
Note. DWI = diffusion-weighted imaging; NAION = non-arteritic anterior ischaemic optic neuropathy; ON = optic neuritis.