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. Author manuscript; available in PMC: 2018 Mar 19.
Published in final edited form as: Science. 2016 Oct 13;354(6313):aah5651. doi: 10.1126/science.aah5651

Figure 3. Quiescence maintenance of dcr1Δ results in rDNA heterochromatinization by H3K9me.

Figure 3

(A) H3K9me2 ChIP-seq enrichment in dcr1Δ vs. wt cells. In G0 cells, but not cycling cells, dcr1Δ strongly accumulates H3K9me2 at the rDNA locus (n=2 biological replicates, cycling cell data from (31)). (B) Validation by H3K9me2 ChIP-qPCR in wild-type and dcr1Δ cycling and G0 cells shows a stronger rDNA H3K9me2 increase in G0 cells in dcr1Δ as compared to wild-type G0 cells (n≥3 biological replicates; ** p<0.01, t-test).