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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Circ Heart Fail. 2018 Mar;11(3):e004153. doi: 10.1161/CIRCHEARTFAILURE.117.004153

Figure 1. Long-term caloric restriction decreases body weight and accordingly heart weight in ischemic HF.

Figure 1

A, Overall design of the 13-months study. B, Body weight (BW) changes during the study period for all groups at 0-, 6- and 12-months after the beginning of the dietary protocol. C, Representative picture of HF-ND (right side) and HF-CR rats (left side) at the end of the study period (12 months after the beginning of the dietary protocol). Measures of (D) Heart weight (HW) and (E) HW normalized to tibia length (TL). F, Graph showing the direct correlation between HW and BW in HF groups (HF-ND group: black spots; HF-CR group: red spots). n. at the end of the study: Sham=10; HF-ND=11; HF-CR=12. Data are presented as mean±SEM *p<0.0001 vs HF-ND, **p<0.01 vs HF-ND, ***p<0.05 vs HF-ND #p<0.01 vs Sham, ##p< 0.001 vs Sham, ^p<0.0001 vs Sham. Two- or one-way ANOVA and Bonferroni test were used between groups.