Table 3.

Effects of insulin on plasma oxylipin levels.

Oxylipin	Oxylipin Level (nM)		Fold Effect	P Value	Precursor FFA
	Basal	Insulin
9-HODE	51 ± 12	678 ± 77	13.3	<0.001	LA
13-HODE	104 ± 19	1193 ± 121	11.5	<0.001	LA
EKODE	8.5 ± 1.5	31 ± 8	3.6	0.025	LA
13-oxo-ODE	11 ± 1	19 ± 2	1.8	0.011	LA
9(10)-EpOME	81 ± 7	134 ± 12	1.6	0.003	LA
12(13)-EpOME	88 ± 8	129 ± 11	1.5	0.014	LA
9,10-DiHOME	32 ± 2	77 ± 6	2.4	<0.001	LA
9,12,13-TriHOME	14 ± 1	18 ± 1	1.3	0.013	LA
9-HOTrE	5.2 ± 1.4	119 ± 16	22.8	<0.001	ALA
13-HOTrE	5.7 ± 1.4	104 ± 14	18.3	<0.001	ALA
9(10)-EpODE	5.3 ± 0.5	16 ± 1	3.0	<0.001	ALA
12(13)-EpODE	4.0 ± 0.4	8.6 ± 0.9	2.2	0.001	ALA
15(16)-EpODE	65 ± 8	42 ± 5	0.7	0.033	ALA
9,10-DiHODE	2.9 ± 0.4	27 ± 3	9.4	<0.001	ALA
12,13-DiHODE	1.3 ± 0.1	2.5 ± 0.3	1.9	0.002	ALA
15,16-DiHODE	7.9 ± 0.6	42 ± 5	5.4	<0.001	ALA
12-oxo-ETE	17 ± 2	27 ± 3	1.6	0.024	ARA
14(15)-EpETrE	16 ± 2	11 ± 1	0.7	0.018	ARA
5-HEPE	9.8 ± 1.6	5.4 ± 1.0	0.6	0.043	EPA
12-HEPE	34 ± 4	20 ± 4	0.6	0.031	EPA
14(15)-EpETE	7.6 ± 0.8	3.1 ± 0.4	0.4	0.001	EPA
17(18)-EpETE	12.7 ± 0.8	6.3 ± 0.7	0.5	<0.001	EPA
11,12-DiHETE	0.35 ± 0.02	0.27 ± 0.02	0.8	0.024	EPA
14,15-DiHETE	0.60 ± 0.05	0.38 ± 0.06	0.6	0.016	EPA
10(11)-EpDPE	7.2 ± 0.5	4.9 ± 0.7	0.7	0.028	DHA
13(14)-EpDPE	4.7 ± 0.4	3.0 ± 0.3	0.6	0.011	DHA
16(17)-EpDPE	6.1 ± 0.5	3.5 ± 0.3	0.6	0.002	DHA
19(20)-EpDPE	10.8 ± 0.7	7.3 ± 0.8	0.7	0.011	DHA
16,17-DiHDPE	0.58 ± 0.03	0.40 ± 0.07	0.7	0.035	DHA
19,20-DiHDPE	2.7 ± 0.1	1.6 ± 0.1	0.6	<0.001	DHA