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. 2018 Mar 13;90(11):e971–e976. doi: 10.1212/WNL.0000000000005121

Figure 2. aDBS efficacy on day 2.

Figure 2

(A) Graph represents average UPDRS III values on day 1 (green line) and day 2 (light gray line) at baseline, at end dose/medication “off,” and at peak dose/medication “on.” Error bars are SEMs. UPDRS III values at end dose/medication “off” on day 1 were significantly different from those on day 2 and from those on peak dose/medication “on” on the same day 1. (B) Graph represents average UDysRS, part III and IV values on day 1 (green line) and on day 2 (light gray line) at baseline, at end dose/medication “off,” and at peak dose/medication “on.” Error bars are SEMs. No significant differences were detected among conditions. (C) Details of the UPDRS III values on day 1 (green line) and on day 2 (light gray line) at baseline, at end dose/medication “off,” and at peak dose/medication “on” in the 2 sessions throughout the whole 8-hour experiment. On day 1, only values at peak dose/medication “on” were different from baseline values, whereas on day 2, the difference was significant at all time points after aDBS was turned on. (D) Histogram represents the average voltage change in the peak dose/medication “on” condition (green) and in the end dose/medication “off” (light gray) during day 2. Error bars are SEMs. aDBS = adaptive deep brain stimulation; HSD = highest significant difference; UPDRS = Unified Parkinson's Disease Rating Scale; UDysRS = Unified Dyskinesias Rating Scale.