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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Neuropharmacology. 2018 May 1;133:85–93. doi: 10.1016/j.neuropharm.2018.01.025

Figure 1. The effects of chronic central administration of DIZE or ubiquitous ACE2 overexpression on the HPA axis.

Figure 1

(A) Plasma CORT levels in response to 30 min restraint and (B) pituitary expression of POMC in mice receiving icv infusion (0.11 μl/h) of normal saline (S) or DIZE (D1, 0.11 μg/h; D10, 1.1 μg/h; D100, 11 μg/h). AUC: Area under the curve indicating the integrated response. (C) Plasma CORT levels in response to 30 min restraint and (D) pituitary expression of POMC in WT and ACE2 KI mice. Bars represent mean and SEM. * = P < 0.05.