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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Neuropharmacology. 2018 May 1;133:85–93. doi: 10.1016/j.neuropharm.2018.01.025

Figure 3. Overexpressing ACE2 in CRH cells attenuates HPA axis activation during restraint stress.

Figure 3

(A) Basal levels of plasma CORT in the morning and in the afternoon of CON and CRH ACE2 KI mice. (B) Plasma CORT levels in response to 30 min restraint and (C) pituitary expression of POMC in CON and CRH ACE2 KI mice. (D and E) Expression of CRH mRNA (punctate red dots) in the PVN of (D) a CON mouse and (E) a CRH ACE2 KI mouse. (F) Integrated density of CRH mRNA signal within the PVN. (G and H) Expression of CRH mRNA (punctate red dots) in the CEA of (G) a CON mouse and (H) a CRH ACE2 KI mouse. (I) Integrated density of CRH mRNA signal within the CEA. Bars represent mean and SEM. * = P < 0.05, ** = P < 0.01, # = P < 0.0001 vs. Morning.