Table 1.
Differential transcription profile of cell cycle pathway genes in METH treated T cells
| Gene symbol | Description | Physiological role | Fold change |
|---|---|---|---|
| G1 phase and G1/S transition | |||
| CDKN3 | Cyclin-dependent kinase inhibitor 3 | Cell cycle regulation: Dephosphorylates CDK2 in a cyclin-dependent manner. | 2.00↑ |
| CUL1 | Cullin 1 | Ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. | 1.98 ↓ |
| S phase and DNA replication | |||
| ABL1 | C-abl oncogene 1, receptor tyrosine kinase | Regulation of cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. | 2.01↑ |
| MCM2 | Minichromosome maintenance complex component 2 | Role in the initiation of DNA replication, replication fork movement, and intimately related to cell proliferation. | 2.02 ↓ |
| MCM4 | Minichromosome maintenance complex component 4 | Central role in the regulation of DNA replication | 2.03 ↓ |
| G2 phase and G2/M transition | |||
| CCNB1 | Cyclin B1 | Essential for the control of the cell cycle at the G2/M (mitosis) transition | 2.01↑ |
| CCNG1 | Cyclin G1 | Modulator of the cell cycle and apoptosis, transcriptional target of p53 tumor suppressor gene | 1.94 ↓ |
| CCNT2 | Cyclin T2 | Regulatory subunit of the cyclin-dependent kinase pair essential for the elongation of transcription and cotranscriptional processing by RNA polymerase II | 1.98↑ |
| CDK5R1 | Cyclin-dependent kinase 5, regulatory subunit 1 (p35) | Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex P-TEFb. | 2.02↑ |
| Cell cycle checkpoint, arrest and regulation | |||
| CCNG2 | Cyclin G2 | Role in growth regulation and in negative regulation of cell cycle. | 2.32↑ |
| RB1 | Retinoblastoma 1 | Negative regulator of the cell cycle, acts as a transcription repressor of E2F1 target genes. | 1.99↑ |
| RBBP8 | Retinoblastoma binding protein 8 | Regulates cell proliferation and complexes with transcriptional co-repressor CTBP. | 1.99 ↓ |
| CCND2 | Cyclin D2 | Control of the cell cycle at the G1/S (start) transition. | 2.00 ↓ |
| BCL2 | B-cell CLL/lymphoma 2 | Regulator of programmed cell death or apoptosis of cells such as lymphocytes by controlling the mitochondrial membrane permeability. | 1.99↓ |
| TFDP1 | Transcription factor Dp-1 | Control of cell-cycle progression from G1 to S phase | 2.02↑ |