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. 2018 Mar 13;12:10. doi: 10.3389/fnint.2018.00010

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Copyright © 2018 Laje, Agostino and Golombek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model features and predictions. (A) Our model qualitatively reproduces the lowering of T3 levels both in a SP and during fasting, as compared with LP levels. (B) Prediction 1. Keeping a LP in an artificially short Zeitgeber period (SH) will produce a winter T3 profile as in normal Zeitgeber period with a SP. (C) When fasting, higher concentrations of striatal DA will lead to normal T3 values. All simulations were performed with the same set of parameter values, except for those parameters that vary because of the proposed manipulations (Supplementary Table S1, Data Sheet 2).