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. 2018 Mar 19;8:4833. doi: 10.1038/s41598-018-23155-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Astrogliosis in Psmc1^fl/fl;CaMKIIα-Cre forebrain. (A) Representative horizontal brain sections immunostained with glial fibrillary acidic protein (GFAP). No significant differences were evident in control cortices; therefore the control image is representative of all ages. Insets show the region of cortex shown (LHS; oval) and a higher magnification image of the neuropathological finding (RHS; white box). Scale bar = 500 (LHS; cortex) and 200 (RHS; hippocampus) µm. Representative immunoblots and quantification of GFAP in control and Psmc1^fl/fl;CaMKIIα-Cre cortices (B) and hippocampi (C). Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was used as a loading control at each age for quantification; a representative GAPDH is shown. Images were cropped from those shown in Supplementary Figure 7. Mean ± SEM of n = 4 mice. *p < 0.05, **p < 0.01 and ***p < 0.001 by unpaired Students t-test.