Table 1.

Metabolic differences between control and Pmsc1^fl/fl;CaMKIIα-Cre mice.

Metabolites	Cortex									Hippocampus									Cerebellum
	4 week			5 week			6 week			4 week			5 week			6 week			6 week
	FC vs. controls	SEM		FC vs. controls	SEM		FC vs. controls	SEM		FC vs. controls	SEM		FC vs. controls	SEM		FC vs. controls	SEM
Glutamine			—	0.46	0.04	↓ Z	0.22	0.01	↓Z	0.85	0.03	↓	0.31	0.05	↓ Z	0.23	0.03	↓ Z	—
NAA	0.52	0.03	↓ Z	0.24	0.03	↓ Z	0.19	0.01	↓Z	0.45	0.06	↓	0.44	0.01	↓	0.54	0.02	↓	—
Serine			—	1.24	0.04	↑	1.41	0.02	↑Z			—	1.27	0.05	↑	1.43	0.07	↑	—
Taurine	0.80	0.01	↓ Z	0.64	0.01	↓ Z	0.64	0.01	↓Z			—	0.80	0.03	↓	0.80	0.03	↓	—
Glycerol			—			—	1.11	0.06	↑Z			—			—	1.19	0.06	↑	—
Glycine			—	1.18	0.03	↑	1.24	0.02	↑			—	1.27	0.03	↑	1.31	0.04	↑	—
Glutamate			—	1.22	0.05	↑	1.28	0.03	↑			—			—			—	—
Creatine			—			—	0.75	0.02	↓			—			—	0.76	0.02	↓	—
Leucine			—			—	1.43	0.04	↑			—			—	1.26	0.07	↑	—
Phenylalanine			—			—	1.69	0.08	↑			—			—	1.64	0.16	↑	—
Histidine			—			—	1.51	0.04	↑			—			—			—	—
Tyrosine			—			—	1.77	0.08	↑			—			—			—	—
Valine			—			—	1.87	0.09	↑	0.89	0.05	↓			—	1.74	0.15	↑	—
Isoleucine			—			—	1.77	0.08	↑	0.81	0.05	↓			—	1.64	0.12	↑	—
Acetate			—			—	0.77	0.02	↓			—			—	0.63	0.04	↓	—
myo-Inositol			—			—	1.16	0.02	↑			—			—	1.26	0.05	↑	—
Adenosine n.			—			—	0.71	0.02	↓			—			—	0.76	0.03	↓	—
Choline-c.	1.35	0.03	↑ Z	1.49	0.04	↑			—			—			—			—	—
Lactate	1.28	0.05	↑	1.47	0.05	↑			—			—	1.25	0.03	↑			—	—
Aspartate	1.17	0.02	↑			—			—			—			—	0.79	0.02	↓	—
Alanine			—			—			—	0.84	0.02	↓			—			—	—

Differences in metabolite concentration in Psmc1^fl/fl;CaMKIIα-Cre mice expressed as fold-change vs. controls. Only metabolites that differed between control and Pmsc1^fl/fl;CaMKIIα-Cre mice with a p < 0.002 by Man-Whitney U test are reported. Arrows indicate the direction of change in Pmsc1^fl/fl;CaMKIIα-Cre mice; ^Z and bold arrows signify a positive Z-statistic. n = Supplementary Table 1. NAA, N-acetyl aspartate; Choline-c., choline-containing compounds.