Figure 1.

Therapeutic agent’s bioavailability: functions un-correlation for optimization: (A) For an optimized bioavailability a therapeutic agent must overcome clearance/metabolization mechanisms and accumulation in healthy tissues responsible for potential toxicity. Optimization of therapeutic agent bioavailability requires modification of its physico-chemical properties. (B) Therapeutic agents, such as small molecules and antibodies require a small size to ensure their chemical mode of action resulting in high level of compromise in their physico-chemical attributes leading to non-optimized biodistribution and poor efficacy - toxicity ratio. Antibody drug conjugate (ADC) and drug delivery system (DDS) have been developed to optimize the biodistribution of existing drugs. These approaches aim at obtaining a better efficacy - toxicity ratio but are still limited since physico-chemical attributes of the object maintain a high level of compromise. Our approach is intended to prime the body to receive the treatment by sequential administration of a nanoprimer and the therapeutic agent. The nanoprimer is designed to physically and transiently occupy organs responsible for therapeutic agent low efficacy/toxicity profile.