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. 2018 Mar 19;8:4797. doi: 10.1038/s41598-018-23140-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nanoprimer: towards therapeutic agent’s bioavailability optimization via a sequential administration. The accumulation of the nanoprimer in liver decreases the clearance of the therapeutic agent to obtain an increased efficacy for a same dose administered or to decrease the toxicity (and extra-cost of adverse events management or product loss) for a same efficacy.