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. 2018 Mar 19;8:4786. doi: 10.1038/s41598-018-22936-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological analysis of cardiac tissue of the transgenic animals. The myofibrils are mostly regular aligned in the transgenic animals (A) and in the wildtype control (B). However, signs of myocyte disarray were detected in the transgenic animals (C) but not in the controls (D) and also mechanically ineffective endings of sarcomeres (E,F). Intriguingly, the nuclei of the cardiomyocytes in the transgenic pigs were often malformed (G), such nuclei can also be found in human HCM-patients with the same mutation (H). The scale bar represents 2 µm unless indicated otherwise.