Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 19;9(4):423. doi: 10.1038/s41419-018-0462-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a, b Expression of PIWIL2 and HDAC3 in tumor and adjacent normal tissues from 30 pairs of cervical cancer patients were examined. The magnification is ×400. *P < 0.05 and **P < 0.01. c PIWIL2 up-regulates HDAC3 expression at protein level in Hela cells and HepG2 cells. d Knockdown of PIWIL2 specifically decreases expression of only HDAC3 among class I HDACs. e Immunofluorescent staining of HDAC3 in PIWIL2 shRNA transfected Hela and HepG2 cells. f PIWIL2 has no effect on HDAC3 mRNA expression (N.S., not significant, P > 0.05). g The degradation of HDAC3 is faster in cells transfected with PIWIL2 shRNA than in cells transfected with control plasmid. Cells transfected with shPIWIL2 or shNC were treated with cycloheximide (CHX) at 50 μM for indicated time