Table 2.
Clinical, radiographic, and physiologic characteristics according to composite physiologic index (CPI).
| CPI ≤ 41 (n = 460) | CPI > 41 (n = 372) | P-value | |
|---|---|---|---|
| Age | 65.6 ± 9.0 | 67.3 ± 9.5 | 0.007 |
| Gender (F:M) | 116 (25.2)/344 (74.8) | 117 (31.5)/255 (68.5) | 0.046 |
| Pulmonary function test | |||
| FVC (%) | 84.1 ± 17.3 | 69.2 ± 16.2 | <0.001 |
| FEV1 (%) | 92.9 ± 18.6 | 81.7 ± 19.4 | <0.001 |
| TLC (%) | 89.8 ± 18.9 | 74.5 ± 16.8 | <0.001 |
| DLCO (%) | 77.0 ± 17.6 | 46.7 ± 11.8 | <0.001 |
| Resting PaO2 mm Hg | 86.5 ± 22.5 | 78.8 ± 20.0 | <0.001 |
| Resting PaCO2 mm Hg | 38.4 ± 7.8 | 36.2 ± 6.9 | 0.001 |
| Radiologic finding | |||
| Reticular pattern | 298 (68.0) | 231 (68.5) | 0.880 |
| Honeycombing change | 323 (74.9) | 277 (78.7) | 0.217 |
| Ground glass opacities | 279 (64.3) | 206 (63.4) | 0.798 |
| Nodular lesions | 94 (23.2) | 70 (22.8) | 0.898 |
| GAP stage (I/II/III) | 388/72/0 | 148/196/28 | <0.001 |
| Death (%) | 112 (24.3) | 161 (43.3) | <0.001 |
CPI, composite physiologic score; CRP, C-reactive protein; DLCO, diffusing capacity of the lung for carbon monoxide; FEV1, forced expiratory volume; FVC, forced vital capacity; GAP, (G, 0–1 point), age (A, 0–2 points), and 2 lung physiology variables (P, FVC and DLCO); PaO2, arterial oxygen tension; PaCO2, arterial carbon dioxide tension; TLC, total lung capacity.