Table 1.
Summary of the clinicopathological characteristics
| Characteristic | No. (%) (n = 242) |
|---|---|
| Sex | |
| Male | 181 (74.8) |
| Female | 61 (25.2) |
| Age at operation, median (range, yr) | 59 (29-87) |
| Preoperative serum AFP level, median (range, ng/mL) | 14.35 (1–40,000) |
| Etiology | |
| Hepatitis B virus (HBV) | 171 (70.7) |
| Alcohol | 35 (14.5) |
| Hepatitis C virus (HCV) | 17 (7.0) |
| HBV + HCV | 1 (0.4) |
| Uncertain etiology | 18 (7.4) |
| Tumor size, median (range, cm) | 3.0 (0.9–17.0) |
| ≤ 2 | 52 (21.5) |
| > 2 and ≤ 5 | 145 (59.9) |
| > 5 | 45 (18.6) |
| Gross type | |
| Vaguely nodular | 9 (3.7) |
| Expanding nodular | 107 (44.2) |
| Multinodular confluent | 78 (32.2) |
| Nodular with perinodular extension | 32 (13.2) |
| Infiltrative | 16 (6.6) |
| Edmondson-Steiner grade | |
| Grade I | 2 (0.8) |
| Grade II | 74 (30.6) |
| Grade III | 142 (58.7) |
| Grade IV | 24 (9.9) |
| Microvascular invasion | |
| Absent | 154 (63.6) |
| Present | 88 (36.4) |
| Portal vein invasion | |
| Absent | 225 (93.0) |
| Present | 17 (7.0) |
| Cirrhosis in background liver | |
| Absent | 109 (45.0) |
| Present | 126 (52.1) |
| Intratumoral fibrous stroma (> 30%) | |
| Absent | 187 (77.3) |
| Present | 55 (22.7) |
| Pathologic T category (AJCC 7th edition) | |
| pT1 | 140 (57.9) |
| pT2 | 82 (33.9) |
| pT3 | 17 (7.0) |
| pT4 | 3 (1.2) |
| Pathologic N category (AJCC 7th edition) | |
| pN0 | 240 (99.2) |
| pN1 | 2 (0.8) |
| Recurrence on follow-up | |
| Absent | 138 (57.0) |
| Present | 104 (43.0) |
| Status at last follow-up | |
| Alive | 160 (66.1) |
| Deceased of disease | 19 (7.9) |
| Deceased of other cause | 5 (2.1) |
| Follow-up loss | 58 (24.0) |
AFP, α-fetoprotein; AJCC, American Joint Committee on Cancer.