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. 2018 Mar 19;8:4802. doi: 10.1038/s41598-018-23037-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma signature for CV stratification. A_D1 and B_D1) Panel of proteins in depleted plasma studied in the discovery phase 1 differentially expressed between the different groups. A_D2 and B_D2) Proteins verified in crude plasma from an independent cohort of patients in discovery phase 2. A_V and B_V) Confirmation of the proteins altered in both types of plasma when analyzed by SRM and turbidimetry. The statistical differences between the groups were calculated using a Student’s t-test.