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. 2018 Mar 19;8:4802. doi: 10.1038/s41598-018-23037-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Panel of proteins that serve as markers of organ damage. (D1) Panel of 35 proteins in depleted plasma differentially expressed in patients with a reported CV event compared with healthy subjects study in discovery phase 1. (D2) 9 proteins verified in the crude plasma of an independent cohort of patients in discovery phase 2. (V) Confirmation of 5 proteins differentially expressed in both types of plasma analyzed by SRM and turbidimetry. The statistical differences between the groups were calculated using a Student’s t-test.