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. 2018 Mar 19;8:4802. doi: 10.1038/s41598-018-23037-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Altered functional categories in patients with CV risk factors and a reported CV event evident using the System Biology Triangle (SBT) model. Distribution of the standardized variable of coordinated proteins (Zca) identifies coordinated protein changes. Categories related to chronic renal failure, coagulation, acute phase response and the immune system in patients with CV risk factors versus healthy subjects, and the cluster of differentially altered proteins related to metabolic process, complement-mediated immunity and coagulation in patients with a reported CV event versus patients with a CV risk factors. Altered categories related to acute renal failure, antioxidation and free radical removal and serine protease inhibitor in patients with a reported CV event versus healthy subjects.