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. 2018 Mar 19;8:4809. doi: 10.1038/s41598-018-23141-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nur77 suppressed the palmitate-induced expression of PPARγ and its target genes in HepG2 cells. (A) HepG2 cells were transfected with pReceiver-M98 or pReceiver-M98-Nur77, and Nur77 expression was measured through a Western blot analysis. The data from each group are presented as the means ± SEs (n = 3). **P < 0.01. (B) Nur77 overexpression decreased the palmitate-induced mRNA expression of PPARγ and its target genes (G0S2, GPR81, GPR109A, and Adipoq). mRNA expression was measured by a quantitative PCR analysis. The data from each group are presented as the means ± SEs (n = 3). *P < 0.05, **P < 0.01. (C) Nur77 overexpression decreased the palmitate-induced protein expression of PPARγ and G0S2. Protein expression was measured through a Western blot analysis. The data from each group are presented as the means ± SEs (n = 3). **P < 0.01.