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. 2018 Mar 19;8:4827. doi: 10.1038/s41598-018-23218-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dietary nucleotide supplementation improved growth performance and villus height of the small intestine in weaned pigs. Weaned pigs were randomly allocated into three groups: control (CON), a corn-soybean meal-based control; NT1, CON + 0.5% NTs; and NT2, CON + 1% NTs. (A) Average daily gain (ADG) of pigs in the three groups over time during the experiment. (B) At the end of the feeding trial (day 42), the levels of cortisol, epinephrine, and norepinephrine were determined by ELISA (n = 10). (C) On day 14, the duodenum jejunum, and ileum were sectioned and stained with H&E (n = 24). Lowercase letters (a, b, and c) indicate significant differences between treatments based on Duncan’s multiple range tests. Error bars indicate standard errors (SEs) of analyses.