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. 2018 Mar 19;8:4840. doi: 10.1038/s41598-018-23305-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Occurrence and organization of the CDGSH domain in Bacteria. A time tree for all bacteria phylum was obtained from TimeTree.org. The presence or absence of the CDGSH domain and its organization within each phylum was determined using the Dictyostelium CISD (XP_647247.1) sequence as the query sequence to perform PSI-BLAST. Bacterial CISD homologs from each phylum were subjected to PFAM domain analysis to identify the domain organization (see methods). Node ages are represented in billion years ago (BYA).