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. 2018 Mar 19;8:4840. doi: 10.1038/s41598-018-23305-6

Figure 3.

Figure 3

Homology of the human Class II (CISD3) and Class I (CISD2) proteins with representative archaeal and proteobacteria CISD proteins. (A) Phylogenetic tree of human CISD3, Archaea, and proteobacteria CISD proteins showing homology between the human CISD3 protein and proteobacteria CISD proteins. For simplification purposes, the different clades were collapsed based on the grouping of archaeal and bacterial sequences. A full version of the tree with complete protein annotations and posterior probabilities (aBayes) values is shown in Supplementary Fig. S5. (B) Phylogenetic tree of human CISD2, Archaea, and proteobacteria CISD proteins showing homology between the human CISD2 protein and archaeal CISD proteins. For simplification purposes, the different clades were collapsed based on the grouping of archaeal and bacterial sequences. A full version of the tree with complete protein annotations and posterior probabilities (aBayes) values is provided as Supplementary Fig. S6. Representative proteobacteria and archaea sequences were obtained as described in the Methods section. Multiple sequence alignment of the human CISD3/CISD2, archaeal, and proteobacteria CISD sequences were performed using MUSCLE and a maximum likelihood tree was generated using PhyML (see methods).