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. 2018 Mar 19;8:4840. doi: 10.1038/s41598-018-23305-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conservation of the CDGSH domain between bacteria, archaea and human. Multiple sequence alignment analysis comparing representative CISD proteins from Aquificae, a bacterium, Thermoprotei, an archaeon, and human CISD1–3 proteins. Multiple sequence alignments were performed using MUSCLE. Red box indicates the transmembrane domain of CISD1 and 2. Bar graph under the aligned sequences indicates degree of conservation (%). Color legend: Background: White - Least conserved, Black - Most conserved; Font: Blue - Least conserved; Red - Most conserved. Representative bacteria and archaea sequences were obtained as described in the Methods section.