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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Methods Mol Biol. 2018;1705:45–72. doi: 10.1007/978-1-4939-7465-8_3

Figure 4.

Figure 4

Left panel: High-resolution X-ray crystallographic structures [22] of the hP2Y1R showing the binding sites for orthosteric antagonist MRS2500 (31) (yellow carbon atoms) and allosteric antagonist (NAM) BPTU (34) (grey carbon atoms). Right panel: Contacts between two co-crystallized ligands and the hP2Y1R.