Table 1. . Top 10 hub genes identified from analysis of each protein–protein interaction network.
| NumUndE | D | BetCen | CluCoe | CloCen | E | NeiCon | TopCoe | Avg.ShoPat |
|---|---|---|---|---|---|---|---|---|
| Hub genes of SI of CRC | ||||||||
| CDK1 | CDK1 | PALB2 | CKS2 | NUP37 | PPAT | FBXO5 | NUP37 | CBX3 |
| NPM1 | NPM1 | CDK1 | NIFK | NUP160 | PAICS | TOP2A | NUP160 | EXOSC3 |
| CCNB1 | CCNB1 | CSE1L | SKP2 | NUP107 | DIMT1 | PTTG1 | NUP107 | EEF1E1 |
| SNRPD2 | SNRPD2 | GNL3 | CENPE | PALB2 | POLR1B | KIF20B | SKP2 | HELLS |
| BUB1 | BUB1 | BCCIP | NUP37 | CD44 | RPP40 | CEP55 | SPC25 | HSPE1 |
| CKS1B | CKS1B | NOP58 | NUP160 | MAD2L1 | HELLS | DDX21 | CENPE | RPP40 |
| DKC1 | DKC1 | NPM1 | DTL | PPARD | EEF1E1 | CPSF3 | DTL | POLR1B |
| RFC4 | GART | DKC1 | NUP107 | NCAPG2 | EXOSC3 | NUDCD1 | NIFK | DIMT1 |
| RFC5 | KIF11 | KPNA2 | SPC25 | SMC2 | CBX3 | CDC25C | NUF2 | EXOSC8 |
| DTL | EXOSC3 | CCNB1 | PPP40 | NUF2 | KIF20B | NUP107 | CDK1 | NPM1 |
| Hub genes of SII of CRC | ||||||||
| UBC | UBC | UBC | CEBPG | UBC | SORBS1 | DNAJC5 | SORBS1 | SLC35D1 |
| YWHAB | YWHAB | AURKA | ATXN3 | YWHAB | WIF1 | JAG1 | ZFP36L2 | ZNF713 |
| AURKA | AURKA | DNAJB12 | NCOA6 | AURKA | KLHL29 | SLC25A23 | PARD6B | MBTPS2 |
| SNRNP200 | SNRNP200 | YWHAB | CASK | SNRNP200 | YWHAB | PROCR | AAR2 | SYK |
| CEBPB | CEBPB | EIF6 | TPX2 | EIF4E2 | AURKA | G2E3 | TPX2 | PXMP4 |
| AMOTL2 | AMOTL2 | SNRNP200 | TLK2 | ARAF | SNRNP200 | TRERF1 | NUF2 | DYNLRB1 |
| TOP1 | COPS6 | EIF4E2 | PDHA1 | CDC25C | EIF4E2 | PIGU | TLK2 | TMEM189 |
| ARAF | ARAF | CEBPB | CTNNBL1 | TNFAIP3 | ARAF | ZNF687 | MAPRE1 | RALGAPB |
| COPS6 | TOP1 | AMOTL2 | HERC5 | CEBPB | CDC25C | DUSP1 | CEBPG | ARFGAP1 |
| EIF4EB | CDC25C | TPX2 | CEBPB | CASK | TOP1 | AURKA | PDHA1 | ZNF687 |
| Hub genes of SIII of CRC | ||||||||
| CABLES2 | ESR1 | TRIM23 | HIP1 | TRIM23 | HIP1 | RPS12 | HIP1 | CABLES2 |
| PCK1 | ARRB1 | ESR1 | ITSN1 | INTS9 | ITSN1 | AKT2 | ITSN1 | PCK1 |
| MGA | RYBP | ARRB1 | YY1 | TGFB1 | EPN1 | PAK1 | MED23 | MGA |
| CDK3 | YY1 | YY1 | E2F2 | INTS10 | PCK1 | IRS1 | FASN | CDK3 |
| EPN1 | CDK3 | AP2B1 | RYBP | ITGB8 | CABLES2 | EPN1 | RYBP | EPN1 |
| HIP1 | HIP1 | MED23 | AP2B1 | ESR1 | AP2B1 | PTAFR | CDK3 | HIP1 |
| ITSN1 | ITSN1 | E2F2 | TRIM23 | DMRT3 | FASN | YY1 | E2F2 | ITSN1 |
| PTAFR | FASN | CDK3 | ESR1 | CCDC25 | PTAFR | HIP1 | YY1 | PTAFR |
| FASN | AP2B1 | FASN | ARRB1 | MED23 | CDK3 | ITSN1 | AP2B1 | FASN |
| AP2B1 | E2F2 | HIP1 | EPN1 | HIP1 | ESR1 | AP2B1 | ESR1 | TRIM23 |
| Hub genes of SIV of CRC | ||||||||
| ATXN1 | ATXN1 | MAP4 | ATXN1 | UBXN1 | SNX2 | LDB1 | HIVEP1 | SCAMP1 |
| SMAD2 | SMAD2 | ATXN1 | SMAD2 | ARHGEF12 | PTPRK | WBSCR16 | FAM193B | SMG9 |
| TRIM23 | TRIM23 | SMAD2 | TRIM23 | SF3B6 | CREB1 | PUM1 | TRIP6 | FAM208B |
| INSR | INSR | FAM193B | INSR | AKT2 | SCAMP1 | LRSAM1 | FAM208B | SNX2 |
| YY1 | YY1 | TRIM23 | YY1 | ANKRD28 | INSR | HIVEP1 | YY1 | PTPRK |
| TRIP6 | TRIP6 | INSR | FAM208B | PHLDA3 | YY1 | FAM193B | INSR | CREB1 |
| FAM208B | FAM208B | YY1 | TRIP6 | MAP4 | RUNX1 | RUNX1 | TRIM23 | AFAP1L1 |
| SCAMP1 | SCAMP1 | TRIP6 | SCAMP1 | TAF9 | TNRC6B | TNRC6B | SMAD2 | TRIM23 |
| UBXN1 | UBXN1 | FAM208B | SMG9 | ARHGEF2 | AFAP1L1 | TRIP6 | ATXN1 | RUNX1 |
| SMG9 | SMG9 | UBXN1 | UBXN1 | YY1 | ATXN1 | SCAMP1 | MAP4 | PTPRK |
Avg.ShoPat: Average shortest path length; BetCen: Betweenness centrality; CloCen: Closeness centrality; CluCoe: Clustering coefficient; D: Degree; E: Eccentricity, NeiCon: Neighborhood connectivity; NumUndE: Number of undirected edge; TopCoe: Topological coefficient.