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. 2018 Mar 13;9:278. doi: 10.3389/fmicb.2018.00278

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Copyright © 2018 Pasquier, Alais, Roux, Thoulouze, Alvarez, Journo, Dutartre and Mahieux.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition efficacy of drugs on HTLV-1 cell-to-cell transmission. (A–E) Luciferase activity was normalized to protein concentration (in μg, quantified by Bradford assay) and expressed as percent of untreated (control) cells set as 100%. Drug concentrations and drug names are indicated. Results were grouped based on the drug family: (A) AZT (1), 3TC (2) and d4T (3) nucleoside analogs, (B) AZT (1) and acyclic nucleoside phosphonates, (C) PMEA and S-PMEA and their prodrugs, (D) PMPA and a series of PMPA pro-drugs, (E) S-PMPA and its pro-drug. Statistical differences were determined using one-way ANOVA (ns, not significant, ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001, n = 2–4 independent experiments with triplicate samples).