Table 1.

Regulated canonical pathways in jejunum

Canonical pathway	Regulation#	p-value	Involved Genes
Hepatic Fibrosis/Hepatic Stellate Cell Activation	L<>M	2.24E-14	ACTA2 (− 2.96); COL15A1 (− 3.35); COL1A1 (− 2.60); COL1A2 (− 2.78); COL3A1 (− 2.48); COL4A2 (− 1.46); COL6A1 (− 1.89); COL6A3 (− 1.87); FLT1 (− 1.72); FN1 (− 2.89); IGF2 (− 2.12); IGFBP3 (− 2.02); KDR (− 1.89); MYL9 (− 1.50); PDGFRA (− 1.83); TGFBR2 (− 1.49)
	L<>H	2.09E-08	ACTA2 (− 2.63); COL15A1 (− 2.73); COL1A2 (− 2.25); COL6A1 (− 1.93); EDNRB (− 2.34); FLT1 (− 1.41); FN1 (− 2.45); IGFBP3 (− 1.89); MMP2 (− 2.20); MYL9 (− 1.46); TGFBR2 (− 1.37)
Complement System	L < M	9.08E-08	C7 (−2.48); C1QA (− 1.77); C1QB (− 2.03); C1QC (− 2.02); C1R (− 2.25); C1S (− 4.36)
	L < H	3.27E-06	C1QA (− 1.71); C1QB (− 1.86); C1QC (− 1.70); C1R (− 1.85); C1S (− 3.08)
RhoA Signaling	L < M	7.72E-07	ABL2 (+ 1.41); ACTA2 (− 2.96); ACTC1 (− 2.64); ARPC1B (− 1.43); MYL9 (− 1.50); PIP5K1A (− 1.26); ROCK2 (+ 1.71); SEPT4 (− 1.57)
	L < H	9.81E-04	ACTA2 (−2.63); MYL9 (− 1.46); NEDD4 (+ 2.11); PFN2 (− 1.56); PLXNA1 (− 1.64)
VEGF Signaling	L < M	1.99E-05	ACTA2 (− 2.96); ACTC1 (− 2.46); FLT1 (− 1.72); KDR (− 1.89); PRKCA (+ 1.35); ROCK2 (+ 1.71)

# - L < M and L < H = z-score ≤ − 2; L<>M and L<>H = no activity pattern available. P-values were calculated using Fisher’s exact test. Fold changes in parentheses indicate positive (L > M or L > H) or negative (L < M or L < H) transcript abundance