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. 2018 Mar 20;18:41. doi: 10.1186/s12935-018-0540-0

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Targeting relationship between miR-200c and XIST. a The relative mRNA expression level of miR-200 was detected using qPCR in sphere and parental cells. b The relative mRNA expression level of XIST was detected using qPCR in bladder cancer stem cell-like side population cells and parental cells. c The targeted binding sites of miR-200c and XIST. d The dual luciferase reporter assays showed that the relative luciferase activity of 5637 and T24 cells co-transfected with XIST-Wt and miR-200c was dramatically decreased compared with that of the control group. Data are presented as mean ± SD. **P < 0.01 vs. parental or control group