Table 5.

Intra- and inter-observer agreement data for scoring of tumour budding

	N	Kappa values (Cut-off ≥10 buds)	Weighted kappa values (Continuous TB-scale)
TB-A1 & TB-A2	129	0.60, p < 0.001	0.70, p < 0.001
TB-A1 & TB-A2	43	0.79, p < 0.001	0.79, p < 0.001
TB-A1 & TB-B	50	0.46, p < 0.001	0.54, p < 0.001
TB-A2 & TB-B	50	0.73, p < 0.001	0.59, p < 0.001

Kappa was calculated for continuous data and for data divided into categories as low-budding and high-budding with a cut-off for high-budding of ≥10 buds. Intra-observer kappa was calculated for all sections (n = 129) and for the deepest invasive tumour section (n = 43). Inter-observer kappa was calculated for 50 randomly selected cases

Abbreviations: TB tumour budding; A1 First count by observer A; A2 second count by observer A; B count by observer B