Fig. 4.

shODC suppresses the tumor-forming ability of ESCC cells. a After inoculation, the body weights of all mice remained stably increased. b shODC significantly suppresses KYSE450 xenograft tumor volume compared with the shMock group. c IHC analysis was performed to determine the expression levels of ODC, PCNA, Ki-67, cleaved caspase 3, and Bcl-2 in ESCC xenograft tumors expressing shMock or shODC. Representative photographs for each antibody and each group are shown. The integrated optical density (IOD) was evaluated using the Image-Pro Plus software (v.6.0) program. All data are shown as mean values ± S.D