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. 2017 Apr 3;1:8. doi: 10.1038/s41698-017-0011-4

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© The Author(s) 2017

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Fig. 3 — Chemoprevention of HER2-positive breast cancer by targeting theTXA₂ pathway. a TBXAS1 is up-regulated in HER2-driven mammary tumorigenesis in an MMTV-Her2/neu transgenic mouse mammary tumor model. Immunohistochemical staining of TBXAS1 in mouse mammary tumors or normal mammary tissues. Original magnification: 200×. b Switching off TXA₂ biosynthesis attenuates HER2-driven breast tumorigenesis. MMTV-HER2/neu transgenic mice were treated with EPA for a total of 60 weeks. c Effects of EPA intake on circulating TXA₂ and PGE₂ levels. d Effects of EPA intake on TBXAS1 or TBXA2R in the MMTV-neu mammary glands and tumors. Because the FVB background of MMTV-Her2/neu transgenic mice, matched non-transgenic FVB mice were used as a baseline to minimize the genetic differences. Production of serum PGs was measured by ELISA as described in “Materials and Methods”. Data are presented as mean values ± S.E.M. The asterisks indicate a significant difference among groups (*p < 0.05, ***p < 0.001)