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. 2018 Mar 20;4:5. doi: 10.1186/s40780-018-0103-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Comparisons of fluconazole doses for neonates and infants estimated using various formulas for children at PMA ranging from 28 to 60 weeks. Open (○) and closed circles (●) connected with solid lines represent doses predicted by fluconazole clearance normalized to body weight (CL_BW) and fluconazole clearance normalized to body surface area (CL_BSA), respectively in the present study. Open (□) and closed squares (■) represent those predicted by the Crawford’s and Augsberger’s formulas, respectively. The shaded area represents doses calculated according to the recommended doses for treating systemic candidiasis for children (3 to 6 mg/kg/day) in the latest prescribing information [3]