Fig. 1.

Prx2-induced neuronal cytotoxicity was mediated by microglia. a The phase-contrast photomicrographs of cultured neuron, scale bar = 100 μm. Treated by Prx2, cultured neuron did not show overt neuronal damage. In neuron-microglia co-culture system, the Prx2 exerted neurotoxicity. b Prx2 had no neurotoxicity when treated with cultured neurons after SAH. c Co-cultured with microglia, the neurons were injured by Prx2 in a dose-dependent manner. d The microglia were activated by Prx2 after SAH. ^###P < 0.001 vs control; **P < 0.01, ***P < 0.001, ^nsP > 0.05 vs indicated groups. Bars represent the mean ± SD. N = 6 in each group