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TLR4-KO in microglia attenuated Prx2-induced microglia-mediated neuronal apoptosis. a TUNEL-staining showed that the number of apoptotic neurons decreased when co-cultured with TLR4-KO microglia after Prx2 exposure. b Quantitative analysis of the proportion of apoptotic neurons. ###P < 0.001 vs control; *P < 0.05, ***P < 0.001, and nsP > 0.05 vs indicated groups. Bars represent the mean ± SD. N = 6 in each group
