Table 1.
Clinical signs, serology and PCR test results recorded in the two orangutans (Pongo pygmaeus pygmaeus) examined in this study
| Animal description | Case 1, male, 36 years | Case 2, female, 34 years | |||
|---|---|---|---|---|---|
| Dates of screening | December 2016 (before diagnosis) | March 2017 (diagnosis) | July 2017 (after treatment) | June 2017 (diagnosis) | October 2017 (after treatment) |
| Clinical signs | Weight loss, apathy, hepato-splenomegaly | Weight loss, apathy, hepato-splenomegaly, bilateral epistaxis | Hepatomegaly | Weight loss, apathy, splenomegaly, pericardial effusion | No signs, no weight gain |
| CBC [reference values (ZIMS)] | |||||
| Red blood count (3.62–5.89) ×1012/l | 2.84 | 2.78 | 4.68 | 2.18 | 3.09 |
| Haematocrit (29.0–44.9) % | 25.1 | 21.1 | 41.8 | 16.3 | 20.3 |
| Haemoglobin (8.9–13.9) g/dl | 7.5 | 6.2 | 11.5 | 4.1 | 5.4 |
| White blood count (3.8–17) ×109/l | 3.2 | 2.0 | 8.1 | 0.538 | 0.42 |
| Platelets (84–309) × 109/l | 101 | 60 | 142 | 77.5 | 76.3 |
| BP [reference values (ZIMS)] | |||||
| Albumin (3.0–5.2) g/dl | 2.4 | 2.1 | 2.7 | 2.1 | 2.4 |
| ALT (6–43) U/L | 51 | 76 | 41 | 17 | 20 |
| AST (4–33) U/L | 66 | 106 | 33 | 18 | 37 |
| Serology results (IFAT) | 1/200 | 1/400 | 1/200 | 1/400 | 1/200 |
| Bone marrow cytology (microscopy) | nt | POS | NEG | POS | NEG |
| PCR results | |||||
| Peripheral blood | POS | POS | nt | POS | POS |
| Bone marrow | nt | nt | POS | POS | POS |
Abbreviations: CBC complete blood counts, BP biochemical profile, POS positive, NEG negative, nt not tested, IFAT immunofluorescence antibody test, ZIMS Species 360 (Zoological Information Management System 2017) [43]