Table 2.

List of drug transport systems and their status in HCC

S. No.	Transporter	Mode of action	Up-regulated or down-regulated	References
1	MDR1 (ABCB1 or P-glycoprotein), MRP1 (ABCC1), MRP2 (ABCC2), MRP3(ABCC3) and ABCG2	Extrudes unrelated anti-tumoral agents like anthracyclines, taxanes, vinca alkaloids etc. from the cell	Up regulated	[18, 100]
2	OATP1B1 and OATP1B3	Transports anti-tumor drugs inside the cells	Down regulated	[101, 102]
3	SLC28 and SLC29	Uptake of nucleoside derived anticancer drugs	Down regulated	[103]
4	Organic cationic transporter-1 (OCT1)	Uptake of tyrosine kinase inhibitors	Down regulated; hyper-methylation of the SLC22A1 promoter	[104]