Table 1.
Frequency of G6PD genotypes in 6 primary health care clinics in Vhembe District, Limpopo Province, South Africa
| Genotypes | HW P(χ2) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Males | Females | |||||||||||
| No. | A− | A+ | B | No. | A−A− | A+A− | BA− | A+A+ | BB | BA+ | ||
| Folovhodwe | 10 | 1 | 4 | 5 | 43 | 0 | 5 | 3 | 0 | 24 | 11 | 0.880 |
| Madimbo | 6 | 0 | 0 | 6 | 51 | 0 | 1 | 6 | 2 | 24 | 18 | NC |
| Mananzhe | 9 | 0 | 3 | 6 | 38 | 0 | 1 | 3 | 2 | 24 | 8 | 0.548 |
| Masisi | 11 | 1 | 2 | 8 | 25 | 0 | 1 | 5 | 1 | 11 | 7 | 0.197 |
| Mulala | 7 | 2 | 2 | 3 | 11 | 0 | 1 | 0 | 3 | 3 | 4 | 0.317 |
| Tshipise | 12 | 2 | 1 | 9 | 25 | 2 | 1 | 5 | 1 | 6 | 10 | 0.009* |
| Totals | 55 | 6 | 12 | 37 | 193 | 2 | 10 | 22 | 9 | 92 | 58 | 0.007* |
G6PD genotypes: male (X*Y) hemizygous deficient A−, male (XY) normal A+ or B; female (X*X*) homozygous deficient = A−/A−; female (X*X) heterozygous deficient = A+/A− or B/A−; and female (XX) normal = A+/A+, B/B or B/A+
NC = not calculated as all males tested in Madimbo clinic carried the G6PD B variant
* P values < 0.05 indicate significant differences from predicted G6PD allele frequencies in females based on male allele frequencies for A−, A+ and B alleles using the Hardy–Weinberg equation (χ2)