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. 2018 Mar 20;17:120. doi: 10.1186/s12936-018-2271-z

Table 1.

Frequency of G6PD genotypes in 6 primary health care clinics in Vhembe District, Limpopo Province, South Africa

Genotypes HW P2)
Males Females
No. A A+ B No. AA A+A BA A+A+ BB BA+
Folovhodwe 10 1 4 5 43 0 5 3 0 24 11 0.880
Madimbo 6 0 0 6 51 0 1 6 2 24 18 NC
Mananzhe 9 0 3 6 38 0 1 3 2 24 8 0.548
Masisi 11 1 2 8 25 0 1 5 1 11 7 0.197
Mulala 7 2 2 3 11 0 1 0 3 3 4 0.317
Tshipise 12 2 1 9 25 2 1 5 1 6 10 0.009*
Totals 55 6 12 37 193 2 10 22 9 92 58 0.007*

G6PD genotypes: male (X*Y) hemizygous deficient A−, male (XY) normal A+ or B; female (X*X*) homozygous deficient = A−/A−; female (X*X) heterozygous deficient = A+/A− or B/A−; and female (XX) normal = A+/A+, B/B or B/A+

NC = not calculated as all males tested in Madimbo clinic carried the G6PD B variant

* P values < 0.05 indicate significant differences from predicted G6PD allele frequencies in females based on male allele frequencies for A−, A+ and B alleles using the Hardy–Weinberg equation (χ2)