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Urolithin A (UroA) related metabolites were converted from ellagitannins in emblic leafflower fruits in vivo. The urine samples in hyperglycemic rats treated with high dose of ELF were collected before sacrifice and further analyzed by HPLC-ESI-Q-TOF-MS. The peaks involved in UroA (m/z 227.0539[M-H]−) in extracted ion chromatogram (EIC) (a) were identified as UroA glucuronic acid (b), UroA-sulfate (b), and UroA (d), respectively.
