Table 1.
Inclusion and exclusion criteria for eligibility of the study.
Inclusion criteria | Exclusion criteria |
---|---|
Age between 18 and 60 years | Currently using pharmacological (e.g., hormone replacement therapy) or supplementation treatment to influence VD metabolism |
Caucasian ethnicity | Disease influencing calcium metabolism, polyendocrinopathy or autoimmune disease and other causes of secondary hyperparathyroidism∗ |
BMI >40 kg/m2 or 35–40 kg/m2 with obesity-associated comorbidity | History of cancer |
Availability and willingness to comply with 18-month outpatient follow-up | Prior head or neck surgery |
Availability and willingness to have blood samples tested for calcium, 25-hydroxy vitamin D, and PTH levels. | Prior abdominal or bariatric surgery |
Availability to take oral supplements, if needed | Lack of calcium metabolism documentation |
Normal preoperative renal function | Lost to follow-up |
∗Causes of secondary hyperparathyroidism according to Fraser [22]: (i) steroid therapy; (ii) patients overclothing; (iii) bisphosphonate therapy; (iv) osteolytic lesions; (v) diuretic therapy; (vi) previous acute pancreatitis; (vii) state of sepsis; (viii) chronic kidney disease and hypercalciuria; (ix) intake of drugs that interact with vitamin D (e.g., phenobarbital and phenytoin); and (x) use of antacids containing aluminum that interfere with phosphate absorption.