Table 2.
Cluster of herbal formula-disease PPI network.
| Cluster | Score | Nodes | Edges | Genes |
|---|---|---|---|---|
| 1 | 30.486 | 38 | 564 | CCND1, STAT1, IGF1, MAP2K1, PIK3CA, BCL2, F2, PTK2, MYC, JAK2, RHOA, PIK3R1, BCL2L1, AKT2, NOS3, AKT1, IGF1R, HMOX1, MMP9, ABL1, KIT, RAF1, IL2, CDC42, GRB2, LCK, MMP2, KDR, ERBB2, ERBB3, STAT5B, RAC1, TP53, PTPN11, MAPK8, MTOR, FOXO3, MET |
|
| ||||
| 2 | 16 | 52 | 408 | Ergosterol peroxide, ethyl oleate (NF), PPARD, PAK1, PDPK1, EPHA2, EGF, RET, SYK, RARA, CCL2, WT1, YAP1, NOS2, glabridin, glycyrrhetinic acid, NME2, BRAF, ZAP70, PPARG, ESRRG, PPARA, HSP90AA1, HCK, CASP3, linoleyl acetate, longikaurin A, mairin, mandenol, CDK6, MOL000273, MOL001910, 508-02-1, 64997-52-0, 8β-ethoxy atractylenolide III, pachymic acid, paeonidanin, palbinone, ESR2, CSK, saikosaponin C, MDM2, PGR, beta-sitosterol, supraene, trametenolic acid, troxerutin, RORA, α-amyrin, FGF1, EGFR, NCOR2 |
|
| ||||
| 3 | 10.421 | 20 | 99 | XIAP, ESR1, MAPK1, FGFR1, MAPK14, MMP1, RAC2, MYB, PTGS2, PTPN1, MAPK12, EIF4E, AR, SRC, ERBB4, INSR, JAK3, GSK3B, SIRT1, ALB |
|
| ||||
| 4 | 9.143 | 43 | 192 | NR1H2, F7, ferulic acid, MAPK10, BTK, MOL000285, RARG, 4-O-methylpaeoniflorin, APAF1, THRA, CASP1, GATA3, MUC1, PLK1, HSP90AB1, PRKACA, PLG, VDR, CTSD, RUNX1, glabrene, CHEK1, PRKCQ, LGALS3, poricoic acid A, glycyrrhizin, ITK, FGFR2, EZH2, RARB, HSPA8, TNFRSF11B, CASP7, sudan III, CA2, ZINC02816192, THRB, HRAS, HNF4G, kaempferol, TEK, licochalcone G, NCOA3 |
|
| ||||
| 5 | 7.829 | 36 | 137 | APRT, IMPDH2, MMP3, NR3C1, NR1H3, ELANE, 7,9(11)-dehydropachymic acid, GMPR2, paeoniflorgenone, paeoniflorin sulfonate, PGF, areapillin, UMPS, quercetin, senkyunolide I, stigmasterol, ARF1, CALM2, DHFR, TGFB2, butylidenephthalide, isoliquiritigenin, (+)-anomalin, isorhamnetin, vestitol, crocetin, 113269-36-6, CANT1, α-spinasterol, ANXA5, NR1I2, ARHGAP1, licochalcone A, 113269-37-7, licoricone, MTHFD1 |
|
| ||||
| 6 | 6.368 | 39 | 121 | MMP8, PARP1, GSTM1, RAN, PPP5C, 3β-acetoxyatractylone, PPIA, CYP2C8, CCNA2, HPRT1, GSS, SULT2A1, BIRC7, 113269-39-9, SETD7, EPHB4, DHODH, REN, GSTO1, petunidin, DPP4, DUT, OTC, GSTT2, ADK, DTYMK, CALM1, PAPSS1, TK1, IMPDH1, hederagenin, MKI67, CDK7, GSTA1, GSTP1, CTSB, AURKA, licochalcone B, MAPKAPK2 |
|
| ||||
| 7 | 4.848 | 34 | 80 | Dehydroeburicoic acid, ergosta-7,22E-dien-3beta-ol, RAP2A, MOL000280, MOL000287, mudanpioside H, HDAC4, NSC684433, octalupine, 18103-41-8, RXRA, PLAU, formononetin, albiflorin, 1-methoxyphaseollidin, HSPD1, paeoniflorin, KAT2B, TOP2A, glycyrin, ammidin, poricoic acid B, poricoic acid C, CTNNA1, sainfuran, sitosterol, isoimperatorin, isolicoflavonol, cerevisterol, 3-methylkempferol, RND3, CDK2, licoisoflavone B, cubebin |
|
| ||||
| 8 | 4.762 | 22 | 50 | SDS, SHMT1, CTSG, AK1, ACE, TYMS, GMPR, MME, GP1BA, METAP2, DCK, PIP, (+)-catechin, ATIC, GART, FKBP1A, PSPH, CBS, ITGAL, NT5M, LYZ, PDE4D |
|
| ||||
| 9 | 3.538 | 14 | 23 | G6PD, RAB5A, ARF4, LDHB, BACE1, AHCY, PKLR, PYGL, RAB11A, HK1, ADAM17, GSR, MMP13, SOD2 |
|
| ||||
| 10 | 3.333 | 4 | 5 | GALK1, GPI, GCK, ME2 |
|
| ||||
| 11 | 3 | 3 | 3 | TPH1, CBR1, SPR |