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. 2018 Mar 6;2018:6195958. doi: 10.1155/2018/6195958

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Copyright © 2018 Vasileios Oikonomou et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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IFN-γ restores defective LAP in p47^phox−/− mice. C57BL/6 and p47^phox−/− mice (n = 6) were infected intranasally with A. fumigatus conidia and treated with rapamycin (10 mg/kg/ip for 3 consecutive days) and IFN-γ (20,000 U/mouse/ip for 7 consecutive days) for one week. Mice were sacrificed 7 days after infection and assessed for (a) survival (%), (b) fungal growth (log10 CFU ± SD), and (c) lung histology (PAS staining; scale bar represents 200 μm). Data are pooled or representative (histology) of three independent experiments. ^∗∗P < 0.001 and ^∗∗∗P < 0.0001. Treated versus untreated (none) mice. One-way ANOVA, Bonferroni post test.