Table 5.
Non-anti-infective potentially inappropriate medications that should be avoided or have their dosage reduced to varying levels of kidney function in geriatric inpatients (n=400) as per Beers criteria in pre-intervention and intervention groups
| Disease | Creatinine clearance (mL/min) |
ADR | Pre-intervention n=200 n (%) |
Intervention n=200 n (%) |
p-value* |
|---|---|---|---|---|---|
| Amiloride | <30 | Hyperkalemia | 4 (2.0) | 2 (1.0) | 0.685 |
| Spironolactone | <30 | Hyperkalemia | 8 (4.0) | 2 (1.0) | 0.105 |
| Dabigatran | <30 | Increased INR | 5 (2.5) | 2 (1.0) | 0.449 |
| Enoxaparin | <30 | Bleeding | 4 (2.0) | 1 (0.5) | 0.372 |
| Triamterene | <30 | Hyperkalemia | 3 (1.5) | 1 (0.5) | 0.623 |
| Levetiracetam | <80 | Anxiety, dizziness | 3 (1.5) | 2 (1.0) | 1.000 |
| Pregabalin | <60 | Dizziness, fatigue | 2 (1.0) | 2 (1.0) | 1.000 |
| Colchicine | <30 | Gastroenteritis | 1 (0.0) | 0 (0.0) | 1.000 |
Note:
*
Fisher’s exact test.
Abbreviations: ADR, adverse drug reaction; INR, international normalized ratio.