Table 1.
Pharmacokinetic parameters in different pharmaceutical forms
| Pharmacokinetic parameters | Pharmaceutical forms
|
|||||
|---|---|---|---|---|---|---|
| Intravenous
|
Sublingual
|
Transdermal
|
||||
| Adults | Children | Adults | Children | Adults | Children | |
| Bioavailability (%) | 100 | 100 | 30–6027,47,48 | 30–5527 | 5049 | |
| Cmax (ng/mL) | 18.1±3.145 | 30051 | ||||
| Tmax (min) | 2–545 | 30–18027,47,48 | 90–36027 | 360051 | 660–126050 | |
| T1/2 (h) | 3.06±0.645 | 1.0±0.254 | 25.351 | 20±827 | ||
| ClT (mL/min·kg) | 18.2±1.245 | 60±1954 | 5027 | 0.1427 | ||
| Vss (L/kg) | 2.7±0.545 | 3.2±254 | 6.2±2.127 | |||
Note: Pharmacokinetic values obtained in clinical studies for adults and children.
Abbreviations: Cmax, maximum plasmatic concentration; Tmax, time to obtain Cmax; T1/2, half-life for buprenorphine; ClT, clearance total; Vss, volume of distribution at steady state.