Figure 1.

(A) In the saline group, the MI, depression, and MI + depression subgroups exhibited levels of serum 5-HT significantly lower than sham-operated rat levels. In the trimetazidine group, depression and MI + depression subgroups had significantly higher serum 5-HT levels than in the sham-operated counterparts. The treatment significantly decreased serum 5-HT for sham operation rats, and significantly increased serum 5-HT for MI, depression, and MI + depression rats compared with the saline group. *P<0.05, indicating a statistically significant difference between the control and trimetazidine group. (B) In the saline group, the MI, depression, and MI + depression rats had significantly lower platelet 5-HT levels compared to sham-operated rats. In the trimetazidine group, depression and MI + depression rats had significantly lower platelet 5-HT levels than sham-operated rats. The treatment significantly increased platelet 5-HT for all disease models compared to the saline group. *P<0.05, indicating a statistically significant difference between the control and trimetazidine group.

Abbreviations: MI, myocardial infarction; 5-HT, 5-hydroxytryptamine.