Figure 2.

(A) In the saline group, MI, depression, and MI + depression rats had higher serum SERT than sham-operated rats but it was not significantly different. In the trimetazidine group, serum levels of SERT were significantly higher than sham-operated rats in the MI, depression, and MI + depression rats. The treatment significantly decreased serum SERT in sham-operated rats, and significantly increased serum SERT in depression rats compared to the control. *P<0.05, indicating a statistically significant difference between the control and trimetazidine group. (B) In the saline group, MI, depression, and MI + depression subgroups had increased platelet SERT levels compared to sham-operated rats but it was not significant. In the trimetazidine group, MI, MI + depression, and depression rats had significant increases in platelet SERT over sham-operated rats. The treatment caused significant decreases in platelet SERT in all disease models compared to the control. *P<0.05, indicating a statistically significant difference between the control and trimetazidine group.

Abbreviations: MI, myocardial infarction; SERT, serotonin transporter.