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Spectral changes induced in CYP3A4 by the investigated compounds. Spectra of the ferric ligand-free CYP3A4 are in black, and those of the ferric ligand-bound, ferrous and ferrous CO bound forms measured at the end of the titration are in red, green and blue, respectively. Insets are equilibrium titration plots and hyperbolic or quadratic fittings, from which spectral dissociation constants (Ks) were calculated (listed in Table 1).
